Immunization to prevent congenital cytomegalovirus infection
نویسندگان
چکیده
منابع مشابه
Congenital cytomegalovirus infection: impairment and immunization.
(See the articles by Ogawa et al., on pages 782–8, and by Schleiss et al., on pages 789–98.) It has been 50 years since Smith [1] and Weller et al. [2] separately reported the isolation and propagation of a cytopath-ogenic virus from tissues of infants with cytomegalic inclusion disease. In the intervening half century, much has been learned about congenital cytomegalovirus (CMV) infection, as ...
متن کاملPassive Immunization During Pregnancy for Congenital Cytomegalovirus Infection
REVIEWER COMMENTS. Vaccine strategies taking into account the enormous variability at the genomic and proteomic levels that many pathogens have evolved are the best hedge against a mere “arms race” in which temporary vaccine efficacy gives way to the emergence of antigenic variants. This is a novel application of such a rational strategy. However, the extent of the challenge is underscored by t...
متن کاملPassive immunization during pregnancy for congenital cytomegalovirus infection.
BACKGROUND Currently, there is no effective intervention for a primary cytomegalovirus (CMV) infection during pregnancy. METHODS We studied pregnant women with a primary CMV infection. The therapy group comprised women whose amniotic fluid contained either CMV or CMV DNA and who were offered intravenous CMV hyperimmune globulin at a dose of 200 U per kilogram of maternal weight. A prevention ...
متن کاملPassive Immunization against Congenital Cytomegalovirus Infection: Current State of Knowledge
Primary infection with the human cytomegalovirus (CMV) occurs in 1–4% of pregnancies. The rates of maternal-fetal CMV transmissions are around 25, 36, 41, and 66%, for infections occurring in the peri-conceptional weeks, first, second, and third trimester of pregnancy, respectively. On the other hand, the severity of fetal organ damage and dysfunction diminishes with increasing gestational age....
متن کاملPassive Immunization against Congenital Cytomegalovirus Infection: Current State of Knowledge.
Primary infection with the human cytomegalovirus (CMV) occurs in 1-4% of pregnancies. The rates of maternal-fetal CMV transmissions are around 25, 36, 41, and 66%, for infections occurring in the peri-conceptional weeks, first, second, and third trimester of pregnancy, respectively. On the other hand, the severity of fetal organ damage and dysfunction diminishes with increasing gestational age....
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ژورنال
عنوان ژورنال: British Medical Bulletin
سال: 2013
ISSN: 0007-1420,1471-8391
DOI: 10.1093/bmb/ldt023